Researchers discover a new line of probiotics for the treatment of obesity or type 2 diabetes
The probiotics as living microorganisms beneficial to health in adequate amounts. In fact, a new study has detected how treat inflammatory diseases with probiotics and metabolic, such as obesity or type 2 diabetes.
The study has been published in the journal Microbiome and led by the DIAMET groupwith researchers from the Pere Virgi Health Research Institute (IISPV)-CERCA, the Rovira i Virgili University (URV) and the Biomedical Research Network Center for Diabetes and Associated Metabolic Diseases (CIBERDEM), supported by La Caixa Foundation .
Decreased succinate in the blood
This research shows that “the metabolic health of people with these diseases could be improved by reducing the levels of succinate in the blood through the administration of specific bacteria that act as probiotics”, as stated IISPV press release.
Succinate is a metabolite with multiple functions and, in metabolic and inflammatory diseases such as obesity and diabetes, the production levels of this metabolite are elevated, which is directly related to the inflammatory characteristic.
When elevated blood levels of this metabolite are detected, it means that the person is not in good metabolic health and that, therefore, in the future they have a higher risk of developing other pathologies.
“In previous research by our group we basically showed that these patients had more succinate-producing bacteria and fewer succinate-consuming, but we had not been able to prove a direct causal relationship. In this research and through the use of microbiota-free obese animal models, we demonstrate for the first time that the intestinal microbiota is the origin of dangerous levels of succinate in obesity and diabetes”, explains Sonia Fernández-Veledo, doctor and coordinator of the study.
“This new line of probiotics is based on the use of succinate-consuming bacteria, which would reduce inflammation and, consequently, improve blood glucose levels and insulin sensitivitytwo aspects that are altered in people with diabetes,” he adds.